Elevated expressions of BTN3A1 and RhoB in psoriasis vulgaris lesions by an immunohistochemical study
Z Tian, W Wong, Q Wu, J Zhou, K Yan… - Applied …, 2022 - journals.lww.com
Psoriasis is a chronic, immune-mediated inflammatory disease which pathogenesis is
closely linked to γδ T cells. Recently, a critical role for butyrophilin 3A1 (BTN3A1) in
mediating the activation of Vγ9Vδ2 T cells, which are reported to redistribute from blood to
the perturbed skin lesions in psoriasis, has been proposed. Additional molecular partners,
including RhoB and periplakin, have also been speculated to interact with BTN3A1 in
modulating Vγ9Vδ2 T-cell activation. Immunohistochemical staining was performed to …
closely linked to γδ T cells. Recently, a critical role for butyrophilin 3A1 (BTN3A1) in
mediating the activation of Vγ9Vδ2 T cells, which are reported to redistribute from blood to
the perturbed skin lesions in psoriasis, has been proposed. Additional molecular partners,
including RhoB and periplakin, have also been speculated to interact with BTN3A1 in
modulating Vγ9Vδ2 T-cell activation. Immunohistochemical staining was performed to …
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